RMP1-14-mIgG1

Description

RMP1-14 is specific clone name for a rat anti-mouse PD-1 (also known as CD279) antibody. The original hybridoma was generated by immunizing Sprague Dawley rats with mouse PD-1-transfected BHK cells. A P3U1 myeloma was used as the fusion partner. Similar to J43, another mAb to mouse PD-1, RMP1-14 blocks the binding of both B7-H1-Ig and B7-DC-Ig to PD-1 transfectants. It has been used extensively to probe the effects of PD-1 inhibition in preclinical murine models.

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Data Gallery

Fig. 1.) 4-20% SDS-PAGE analysis
Recombinant protein was visualized by Coomassie Brilliant Blue R250 staining.

Data Gallery

Fig. 2.)    SEC-HPLC analysis
Column: Superdex 200 Increase 5/150 GL
Running buffer: 2xPBS, pH 7.4