Etanercept

Description

This is a recombinant protein using the same sequences as the therapeutic protein etanercept. It is a dimeric fusion protein composed of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1. Etanercept is clinically employed to treat or manage a variety of inflammatory conditions, including rheumatoid arthritis (RA), ankylosing spondylitis (AS), and juvenile idiopathic poly-articular arthritis (JIA). By binding to two TNF molecules, it effectively eliminates them from circulation. Notably, etanercept is only capable of binding to the active trimeric form of TNF as its binding site is located in the cleft between subunits.

Contact Us for a Quote!

Please enable JavaScript in your browser to complete this form.
Name

Data Gallery

Fig. 1.) 4-20% SDS-PAGE analysis
Recombinant protein was visualized by Coomassie Brilliant Blue R250 staining.

Fig. 2.)    SEC-HPLC analysis
Column: Superdex 200 Increase 5/150 GL
Running buffer: 2xPBS, pH 7.4