His Kras(2-185) G12D
Description
K-Ras belongs to the small GTPase superfamily, Ras family. It is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes because of the presence of an isoprenyl group on its C-terminus. K-Ras functions as a molecular on/off switch. KRAS mutation occurs in nearly 30% of human cancers, while KRAS(G12D) is the most prevalent and oncogenic variant.
Product name | Recombinant Human KRAS G12D protein |
Tag | His at N-terminus |
Amino Acids | 2 to 185 |
MW | 23319.34Da |
Species | Human |
Accession | P01116-2 |
Synonyms | C-K-RAS Protein; K-RAS Protein; K-RAS4B Protein; NS Protein; RASK2 Protein |
Description | The recombinant KRAS G12D protein, encompassing amino acids 2-185 (end), contains a His tag at N-Terminus and mutation of interest G12D. It was purified by unique purification methods. |
Source | Escherichia coli |
Purity | >90.0% as determined by SDS-PAGE |
Formulation | 20 mM HEPES pH 7.4, 150 mM NaCl, 0.5 mM MgCl2, 1 mM TCEP |
Stability | At least 6 months at -80°C |
Delivery Time | 1 week if in stock; 4 weeks if production needed |
Reference | No |
Note | For research use only. Not suitable for clinical or therapeutic use. |
Size | 100ug, 500ug, 1mg, 5mg, 10mg |
Brand | BioMetas |
Clonality | Recombinant Protein |
Expression system | Escherichia coli |
Applications | SDS-PAGE, ELISA, Western Blot |
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Data Gallery
Fig. 1.) SDS-PAGE analysis
On SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.
Fig. 2.) SEC-HPLC analysis
The purity of this product is more than 95% verified by SEC-HPLC.
