Nirsevimab

Description

This is a humanized IgG1 antibody using the same sequences as the therapeutic antibody nirsevimab. It is a monoclonal antibody with activity against the respiratory syncytial virus (RSV) fusion protein. RSV is a major cause of lower respiratory tract infection and hospitalization in infants. Nirsevimab is designed to bind the F1 and F2 subunits on the RSV’s surface at a highly conserved epitope and locks the RSV F protein in the prefusion conformation to block viral entry into the host cell. It has a modified Fc region, extending the half-life of the drug in order to last the whole RSV season.

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Data Gallery

Fig. 1.) 4-20% SDS-PAGE analysis
Recombinant protein was visualized by Coomassie Brilliant Blue R250 staining.

Fig. 2.)    SEC-HPLC analysis
Column: Superdex 200 Increase 5/150 GL
Running buffer: 2xPBS, pH 7.4