Teclistamab

Description

Teclistamab is humanized immunoglobulin (Ig) G4, lambda bispecific antibody targeted on CD3 receptor expressed on the surface of T cell and B-cell maturation antigen (BCMA) expressed on malignant multiple myeloma cells. As Teclistamab binding both targets, it is able to draw T cell expressed CD3 in close proximity to target cells expressed BCMA, resulting in T cell activation and T cell-mediated cytotoxincity, which ultimately promotes the lysis and death of BCMA expressed cell.

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Data Gallery

Fig. 1.) 4-20% SDS-PAGE analysis
Recombinant protein was visualized by Coomassie Brilliant Blue R250 staining.

Fig. 2.)    SEC-HPLC analysis
Column: Superdex 200 Increase 5/150 GL
Running buffer: 2xPBS, pH 7.4