This is a humanized IgG2 monoclonal antibody using the same sequences as the therapeutic antibody satralizumab. It specifically binds to both soluble and membrane-bound interleukin-6 (IL6) receptors, effectively inhibiting the signaling cascade and subsequent pro-inflammatory effects associated with endogenous IL6 binding. Satralizumab is indicated for the treatment of neuromyelitis optica spectrum disorder (NMOSD), a rare autoimmune inflammatory disorder affecting the central nervous system (CNS) characterized by demyelinating lesions in the optic nerve, spinal cord, brainstem, and cerebrum. It possesses a uniquely formulation of “recycling antibody technology”, enabling pH-dependent association with IL6 receptors. This mechanism allows satralizumab to bind an IL6 receptor until it reaches an endosome, where dissociation from the receptor occurs before re-entering plasma for further action. This innovative approach significantly prolongs the duration of action, by allowing single drug molecules to interact with multiple endogenous IL6 receptors prior to elimination.
Product name | Satralizumab Biosimilar |
Species | Homo sapiens |
Expression system | CHO-K1 |
Buffer | PBS, pH 7.4 |
Delivery condition | Dry ice (-80°C) |
Delivery Time | 1 week if in stock; 4 weeks if production needed |
Storage condition | Store at -80°C |
Brand | BioMetas |
Applications | ELISA, assay, in vivo |
Aliases/Synonyms | Enspryng™, SA-237, satralizumab-mwge, sapelizumab |
Reference | |
Note | For research use only. Not suitable for clinical or therapeutic use. |
Isotype | IgG2 |
Clonality | Monoclonal Antibody |
Size | 1mg, 5mg, 10mg, 50mg, 100mg |
Brand | BioMetas |
Product type | Biosimilar |
Clonality | Monoclonal Antibody |
Expression system | CHO-K1 |
Applications | Elisa, assay, in vivo |
Amount | Price |
1mg | ¥1200 |
5mg | ¥3000 |
10mg | ¥5000 |
25mg | ¥7500 |
50mg | ¥10000 |
100mg | ¥14000 |
Fig. 1.) 4-20% SDS-PAGE analysis
Recombinant protein was visualized by Coomassie Brilliant Blue R250 staining.
Fig. 2.) SEC-HPLC analysis
Column: Superdex 200 Increase 5/150 GL
Running buffer: 2xPBS, pH 7.4